Bradycardia: changes in intrinsic rate rather than cardiac autonomic modulation

Leicht, Anthony S. (2013) Bradycardia: changes in intrinsic rate rather than cardiac autonomic modulation. Clinical Autonomic Research, 23 (6). p. 343.

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The recent cross-sectional comparison by Molina et al. [1] highlights again the growing evidence for a reduced, cardiac intrinsic rate responsible for exercise-induced bradycardia (EIB). Several longitudinal studies [2–4] have previously shown EIB without alterations in cardiac autonomic modulation as evidenced by heart rate variability (HRV). While HRV changes have been reported to be dependent on exercise training intensity [5] and initial high HRV levels in young healthy adults [2, 6], these past and current results point to localised changes within the myocardium as the primary contributor to EIB. Chronic, mechanical stretching of the sino-atrial node [2–4], changes in ionic concentration within the sino-atrial node [7], and localised changes in myocardial conduction [8] appear to play a role in the development of EIB. The current work of Molina [1] adds to that of others previously and further highlights the necessity to examine sino-atrial function as a key mechanism for EIB.

Item ID: 31071
Item Type: Article (Commentary)
ISSN: 1619-1560
Date Deposited: 06 Feb 2014 06:24
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1106 Human Movement and Sports Science > 110602 Exercise Physiology @ 100%
SEO Codes: 92 HEALTH > 9299 Other Health > 929999 Health not elsewhere classified @ 100%
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