Insulinoma presenting with long-standing depression, primary hypogonadism and Sertoli cell only syndrome

Malabu, Usman H., Gowda, Durgesh, and Tan, Yong Mong (2013) Insulinoma presenting with long-standing depression, primary hypogonadism and Sertoli cell only syndrome. Case Reports in Endocrinology, 2013. 926385. pp. 1-3.

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The aim was to report an unusual case of insulinoma presenting with long-standing depression and primary testicular failure. We describe a 34-year old male with clinical, laboratory, and radiologic data consistent with islet cell tumor and seminiferous tubule failure primary hypogonadism. The literature is reviewed relative to the component of this syndrome, and a possible association is discussed. The subject was investigated for a long standing history of depression requiring medical attention because of mental confusion and slurred speech and was found to have an insulinoma. He was diagnosed to have primary gonadal failure and physical examination showed no evidence of dysmorphic features. Chromosomal analysis revealed normal 46 XY and testicular biopsy showed Sertoli cell only syndrome (SCOS). Biochemistry revealed endogenous hyperinsulinism and histology confirmed an islet cell tumor. He remained euglycemic postoperatively and on follow-up. From this report, we emphasize drawing clinicians' attention to the possibility of an association between insulinoma and primary testicular failure and suggest consideration of this diagnosis in patients with hypergonadotropic hypogonadism who may present with infertility.

Item ID: 30703
Item Type: Article (Case Study)
ISSN: 2090-651X
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Copyright © 2013 Usman H. Malabu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Date Deposited: 31 Mar 2014 08:02
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110306 Endocrinology @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920104 Diabetes @ 100%
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