Clinical need for ototopical fluoroquinolones outweighs miniscule risk of antibiotic resistance

Couzos, Sophie, and Councillor, Henry (2006) Clinical need for ototopical fluoroquinolones outweighs miniscule risk of antibiotic resistance. Journal of Paediatrics and Child Health, 42 (4). pp. 223-224.

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Abstract

[Extract] The National Aboriginal Community Controlled Health Organisation (NACCHO), in a double-blind randomized controlled trial, showed that the use of topical ciprofloxacin to treat chronic suppurative otitis media (CSOM) among 111 Aboriginal children improved the odds of clinical cure three fold compared with the current standard of topical aminoglycoside. Treatment did not lead to resistant isolates isolates when followed up for 21 days, even among those with persistent discharge. Given the demonstrated efficacy and concerns about ototoxicity of aminoglycosides, it was recommended that ototopical ciprofloxacin be used as first-line treatment (in conjunction with ear toilet) for CSOM. Dr Coates correctly concludes in his review article that the theoretical concerns of resistance emerging from ototopical fluoroquinolones in this setting were considerably outweighed by the risk of bacterial resistance emerging from oral use.

Item ID: 30405
Item Type: Article (Editorial)
ISSN: 1440-1754
Date Deposited: 24 Sep 2015 04:25
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111717 Primary Health Care @ 100%
SEO Codes: 92 HEALTH > 9205 Specific Population Health (excl. Indigenous Health) > 920501 Child Health @ 100%
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