Anisakis: a food-borne parasite that triggers allergic host defences

Nieuwenhuizen, Natalie E., and Lopata, Andreas L. (2013) Anisakis: a food-borne parasite that triggers allergic host defences. International Journal for Parasitology, 43 (12-13). pp. 1047-1057.

[img] PDF (Published Version) - Published Version
Restricted to Repository staff only

View at Publisher Website:


Anisakis is a parasitic nematode which infects fish and marine invertebrates, including crustaceans and molluscs. Ingestion of contaminated seafood can cause acute gastrointestinal diseases. Infection can be accompanied by severe allergic reactions such as urticaria, angioedema and anaphylaxis. Diagnosis of allergy due to Anisakis currently relies on the detection of serum IgE antibodies to allergenic proteins and a history of reactions upon exposure to fish. Anisakis proteins demonstrate considerable immunological cross-reactivity to proteins of related nematodes and other invertebrates such as crustaceans and house dust-mites. In contrast, very limited molecular associations with other parasite groups are observed, including trematodes and cestodes. This review outlines current knowledge on Anisakis as a food-borne parasite, with special focus on the underlying immunological mechanisms resulting in allergic host defence responses.

Item ID: 30388
Item Type: Article (Research - C1)
ISSN: 0020-7519
Keywords: anisakis, allergy, allergen, tropomyosin, paramyosin, Th2 response, parasite, IgE antibody
Funders: National Research Foundation, South Africa, Australian Biological Resource Study (ABRS)
Date Deposited: 27 Nov 2013 05:28
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1101 Medical Biochemistry and Metabolomics > 110106 Medical Biochemistry: Proteins and Peptides (incl Medical Proteomics) @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110701 Allergy @ 50%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 50%
92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 50%
Downloads: Total: 1
More Statistics

Actions (Repository Staff Only)

Item Control Page Item Control Page