A genome-wide analysis of annexins from parasitic organisms and their vectors

Cantacessi, Cinzia, Seddon, Jennifer M., Miller, Terrence L., Leow, Chiuan Yee, Thomas, Laëtitia, Mason, Lyndel, Willis, Charlene, Walker, Giselle, Loukas, Alex, Gasser, Robin B., Jones, Malcolm K., and Hofmann, Andreas (2013) A genome-wide analysis of annexins from parasitic organisms and their vectors. Scientific Reports, 3. 2893. pp. 1-8.

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Abstract

In this study, we conduct an in-depth analysis of annexin proteins from a diverse range of invertebrate taxa, including the major groups that contain the parasites and vector organisms that are harmful to humans and domestic animals. Using structure-based amino acid sequence alignments and phylogenetic analyses, we present a classification for this protein group and assign names to sequences with ambiguous annotations in public databases. Our analyses reveal six distinct annexin clades, and the mapping of genes encoding annexins to the genome of the human blood fluke Schistosoma mansoni supports the hypothesis of gene duplication as a major evolutionary event in annexin genesis. This study illuminates annexin diversity from a novel perspective using contemporary phylogenetic hypotheses of eukaryote evolution, and will aid the consolidation of annexin protein identities in public databases and provide a foundation for future functional analysis and characterisation of these proteins in parasites of socioeconomic importance.

Item ID: 30344
Item Type: Article (Research - C1)
ISSN: 2045-2322
Keywords: classification and taxonomy; molecular evolution; protein folding; cytoskeletal proteins
Additional Information:

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

Funders: National Health and Medical Research Council (NHMRC), Australian Research Council (ARC), Queensland Government, Malaysian Government, Universiti Sains Malayasia
Projects and Grants: NHMRC Early Career Fellowship, NHMRC Principal Research Fellowship, Queensland Government Smart Futures Fellowship, Malaysian Government and Universiti Sains Malayasia ASTS Scholarship
Date Deposited: 28 Nov 2013 05:21
FoR Codes: 06 BIOLOGICAL SCIENCES > 0604 Genetics > 060408 Genomics @ 30%
11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110309 Infectious Diseases @ 40%
06 BIOLOGICAL SCIENCES > 0601 Biochemistry and Cell Biology > 060102 Bioinformatics @ 30%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 60%
96 ENVIRONMENT > 9604 Control of Pests, Diseases and Exotic Species > 960499 Control of Pests, Diseases and Exotic Species not elsewhere classified @ 40%
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