Effects of chronic nicotine administration on hypothalamic neuropeptide Y levels in the rat

Dryden, S., McCarthy, H.D., Kilpatrick, A., Malabu, U., MacFarlane, I., and Williams, G. (1993) Effects of chronic nicotine administration on hypothalamic neuropeptide Y levels in the rat. Clinical Science, 84 (Supplement No. 28). 159. p. 44.

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Nicotine administration has an inverse relationship with body weight. Cigarette smoking reduces food intake, and a carbohydrate-specific craving often develops after cessation of smoking. The effect of nicotine administration on hypothalamic Neuropeptide Y (NPY) levels, an endogenous potent appetite stimulant, particularly for carbohydrate was assessed in a 12 day study in rats.

Three groups of rats were implanted (s.c.) with mini-osmotic pumps, one group containing nicotine dihydrochloride (12mg/kg /day n=8) and two groups containing saline (0.9% n=8,8). The nicotine treated rats and one of the saline groups were allowed to free-feed for twelve days.

The second saline treated group were pair-fed to the level of food intake of the nicotine treated rats.

Food intake in the nicotine treated rats was reduced by 11 % over the twelve days (p=0.02), and body weight gain reduced by 10% over the twelve days (p<0.02). NPY levels were significantly lower in the nicotine treated and pair-fed rats compared with the control rats (PVN 62 ± 6.5 vs 91.2 ± 6.3 fmol/ug protein p<0.01, ARC 33 ± 4.9 vs 49 ± 4.0 fmol/ug protein p=0.01. pair-fed PVN 74 ± 3.7 vs 91.2 ± 6.3 p=0.03).

These results suggest that the hypophagia associated with nicotine treatment may be a result of reduced hypothalamic NPYergic activity.

Item ID: 29863
Item Type: Article (Abstract)
ISSN: 1470-8736
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This special issue of Clinical Science contains communications of the Medical Research Society Meeting held on 5 and 6 November 1992.

Date Deposited: 31 Mar 2014 07:33
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110306 Endocrinology @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920104 Diabetes @ 100%
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