Association of single nucleotide polymorphisms in the gene encoding platelet endothelial cell adhesion molecule-1 with the risk of myocardial infarction: a systematic review and meta-analysis

Sahebkar, Amirhossein, Morris, Dylan R., Biros, Erik, and Golledge, Jonathan (2013) Association of single nucleotide polymorphisms in the gene encoding platelet endothelial cell adhesion molecule-1 with the risk of myocardial infarction: a systematic review and meta-analysis. Thrombosis Research, 132 (2). pp. 227-233.

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Abstract

Background: Single nucleotide polymorphisms (SNPs) within the platelet endothelial cell adhesion molecule-1 (PECAM-1) gene have been proposed as predisposing factors for myocardial infarction (MI) but published reports have given conflicting findings.

Objective: The present study aimed to clarify the association between SNPs in PECAM-1 and MI using a meta-analysis of published studies.

Methods: Medline, HuGE Navigator and SCOPUS Library databases were searched to identify case-control studies which examined the association of SNPs in PECAM-1 and MI. Data were extracted using standardized methods. Combined odds ratios (OR) with 95% confidence intervals (CI) for the association of SNPs with MI were calculated using a random effect approach and under additive, dominant and recessive models of inheritance.

Results: A total of 7 studies comprising 3886 cases and 4097 controls fulfilled the inclusion criteria. Three SNPs in PECAM-1 were investigated, namely rs668 (Leu125Val), rs12953 (Ser563Asn) and rs1131012 (Arg670Gly). The GG genotype of rs1131012 was associated with a reduced risk of MI under a recessive (OR: 0.81; 95%CI: 0.69-0.94; p = 0.010), but not additive and dominant models (p > 0.05). This association was robust in sensitivity analyses and not subject to heterogeneity. No significant association was detected between rs668 and rs12953 with MI under any of the inheritance models.

Conclusion: The results of the current meta-analysis suggest that homozygous polymorphic genotype (GG) of the rs1131012 SNP may confer protection against MI. The impact of this variant on the expression and function of PECAM-1 needs to be elucidated in future investigations.

Item ID: 29778
Item Type: Article (Research - C1)
ISSN: 1879-2472
Keywords: cardiovascular disease, atherothrombosis, systematic review, meta-analysis, cell adhesion molecule
Funders: National Health and Medical Research Council (NHMRC), BUPA Foundation, Office of Health and Medical Research, Queensland Government
Projects and Grants: NHMRC grant 540404, NHMRC grant 1021416, NHMRC Practitioner Fellowship 1019921
Date Deposited: 09 Oct 2013 05:26
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl Cardiovascular Diseases) @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 100%
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