Malaria in the Australian Defence Force: the Bougainville experience

Elmes, Nathan J., Bennett, Sonya M., and Nasveld, Peter E. (2004) Malaria in the Australian Defence Force: the Bougainville experience. ADF Health, 5 (2). pp. 69-72.

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During a 5-year period, almost 4000 Australian personnel served in the Papua New Guinean province of Bougainville.

1.The first randomised, double-blind trial comparing Malarone (a combination of atovaquone and proguanil) with doxycycline was conducted during the deployment. Malarone was as effective as doxycycline and better tolerated.

2.Another trial compared a 3-day course of tafenoquine with the course of primaquine that was standard at that time for post-exposure prophylaxis. There was no statistical difference in rates of malaria following either regimen.

3. There were 64 episodes of malaria affecting 50 individuals. This gave an attack rate of 41.6 malarious episodes per 1000 man years. Most attacks occurred after the person had returned to Australia. 4.The dosage of primaquine was increased partway through the deployment, from 22.5mg to 30mg per day.

The attack rate fell from 67.1 to 13.2 per 1000 man years. The attack rate following tafenoquine post-exposure ADF Health 2004; 5: 69-72 prophylaxis was 63.5 per 1000 man years.

Item ID: 29759
Item Type: Article (Research - C1)
ISSN: 1443-1033
Date Deposited: 10 Oct 2013 23:17
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111716 Preventive Medicine @ 100%
SEO Codes: 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920412 Preventive Medicine @ 100%
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