Andrews, Philip C., Deacon, Glen B., Ferrero, Richard. L., Junk, Peter C., Kumar, Ish, Karrar, Abdulgader, and MacLellan, Jonathan G. (2009) Bismuth(III) 5-sulfosalicylate complexes: structure, solubility and activity against Helicobacter pylori. Dalton Transactions, 2009 (32). pp. 6377-6384.

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Abstract

Treatment of 5-sulfosalicylic acid (H3Ssal) with BiPh3 results in the formation of the first dianionic carboxylate–sulfonate bismuth complex, [PhBi(HSsal)H2O]∞1a, and its ethanol analogue [PhBi(HSsal)EtOH]∞1b (space groupP21/c), while Bi(OAc)3 gives the mixed monoanionic and dianionic complex, {[Bi(HSsal)(H2Ssal)(H2O)3]2·2H2O}∞2 (space groupP[1 with combining macron]). The three complexes are all polymeric in the solid state as determined by single crystal X-ray diffraction, with extended frameworks constructed from dimeric [Bi(HSsal)]2, 1a and 1b, or from [Bi(HSsal)(H2Ssal)]2 units, 2. The heteroleptic bismuth complexes 1a and 2 display remarkable aqueous solubility, 10 and 2.5 mg ml−1 respectively, resulting in a clear solution of pH 1.5. In contrast, 1b is essentially insoluble in aqueous environments. All three complexes show significant activity against the bacterium Helicobacter pylori of <6.25 µg ml−1.

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