Molecular epidemiology of influenza A (H5N1) viruses, Bangladesh, 2007-2011

Hoque, Md. Ahasanul, Tunh, Hein Min, Hassan, Mohammad Mahmudul, Khan, Shahneaz Ali, Islam, S. K. M. Azizul, Islam, Md. Nurul, Debnatha, Nitish Chandra, Giasuddin, Md., Osmani, T.A.B.M. Muzaffar Goni, Islam, Ariful, Thornton, Ronald Norman, Burgess, Graham William, Skerratt, Lee Francis, Selleck, Paul, Brun, Edgar, and Leung, Frederick Chi-Ching (2013) Molecular epidemiology of influenza A (H5N1) viruses, Bangladesh, 2007-2011. Preventive Veterinary Medicine, 111 (3-4). pp. 314-318.

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Abstract

To investigate the origins, evolution and patterns of spread of HPAI H5N1 outbreaks in Bangladesh, we performed a phylogenetic reconstruction analysis using Bayesian methods. The analysis was conducted using 81 hemagglutinin (HA) gene sequences from the H5N1 viruses isolated in Bangladesh from 2007 to 2011, together with 264 publicly available HA sequences of clade 2.2, 2.3.2 and 2.3.4 retrieved from GenBank. Our study provides evidence that clade 2.2.2 viruses that caused outbreaks in Bangladesh were lineages independent from the viruses introduced earlier into India. Furthermore, the Bangladesh clade 2.2.2 descendents subsequently spread to India and Bhutan. This has implications for avian influenza control in southern Asia suggesting multiple routes of entry of the virus including one pathway that spread to neighboring countries via Bangladesh.

Item ID: 29172
Item Type: Article (Refereed Research - C1)
Keywords: phylogenetic reconstruction, Influenza A (H5N1)
ISSN: 1873-1716
Date Deposited: 04 Sep 2013 05:26
FoR Codes: 07 AGRICULTURAL AND VETERINARY SCIENCES > 0707 Veterinary Sciences > 070704 Veterinary Epidemiology @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111706 Epidemiology @ 50%
SEO Codes: 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920405 Environmental Health @ 100%
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