Making Bispirin: synthesis, structure and activity against Helicobacter pylori of bismuth(III) acetylsalicylate
Andrews, Philip C., Blair, Victoria L., Ferrero, Richard L., Junk, Peter C., and Kumar, Ish (2013) Making Bispirin: synthesis, structure and activity against Helicobacter pylori of bismuth(III) acetylsalicylate. Chemical Communications, 49 (28). pp. 2870-2872.
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DOI: 10.1039/c3cc40645h
View at Publisher Website: http://dx.doi.org/10.1039/c3cc40645h
Abstract
Reaction of Bi((OᵗBu)₃ with aspirin (acetylsalicylic acid = aspH) in dry toluene results in the bismuth(III) complex, [Bi(O₂C(C₆H₄)OAc)₃]∞ 1 (O₂C(C₆H₄)OAc = asp), minimum inhibitory concentration (MIC) against Helicobacter pylori >= 6.25 mu g mL⁻¹), while the inclusion of a stoichiometric equivalent of (KOᵗBu)leads to crystals of the bismuthate salt [KBi(O₂C(C₆H₄)OAc)₄]∞ 2.
Item ID: | 28353 |
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Item Type: | Article (Research - C1) |
ISSN: | 1364-548X |
Keywords: | bismuth, helicobacter pylori, salicylate |
Date Deposited: | 17 Jul 2013 05:25 |
FoR Codes: | 03 CHEMICAL SCIENCES > 0302 Inorganic Chemistry > 030204 Main Group Metal Chemistry @ 100% |
SEO Codes: | 97 EXPANDING KNOWLEDGE > 970103 Expanding Knowledge in the Chemical Sciences @ 100% |
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