Translational neuropsychiatry of genetic and neurodevelopmental animal models of schizophrenia

Gottschalk, Michael G., Sarnyai, Zoltan, Guest, Paul C., Harris, Laura W., and Bahn, Sabine (2013) Translational neuropsychiatry of genetic and neurodevelopmental animal models of schizophrenia. Revista de Psiquiatria Clinica, 40 (1). pp. 41-50.

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Psychiatric symptoms are subjective by nature and tend to overlap between different disorders. The modelling of a neuropsychiatric disorder therefore faces challenges because of missing knowledge of the fundamental pathophysiology and a lack of accurate diagnostics. Animal models are used to test hypotheses of aetiology and to represent the human condition as close as possible to increase our understanding of the disease and to evaluate new targets for drug discovery. In this review, genetic and neurodevelopmental animal models of schizophrenia are discussed with respect to behavioural and neurophysiological findings and their association with the clinical condition. Only specific animal models of schizophrenia may ultimately lead to novel diagnostic approaches and drug discovery. We argue that molecular biomarkers are important to improve animal to human translation since behavioural readouts lack the necessary specificity and reliability to assess human psychiatric symptoms.

Item ID: 28343
Item Type: Article (Research - C1)
ISSN: 1806-938X
Keywords: translational research, neuropsychiatry, genetic neurodevelopment, animal model, schizophrenia
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Also available in Portuguese.

Abstract [Portuguese]: Sintomas psiquiátricos são subjetivos por natureza e tendem a se sobrepor entre diferentes desordens. Sendo assim, a criação de modelos de uma desordem neuropsiquiátrica encontra desafios pela falta de conhecimento dos fundamentos da fisiopatologia e diagnósticos precisos. Modelos animais são usados para testar hipóteses de etiologia e para representar a condição humana tão próximo quanto possível para aumentar nosso entendimento da doença e avaliar novos alvos para a descoberta de drogas. Nesta revisão, modelos animais genéticos e de neurodesenvolvimento de esquizofrenia são discutidos com respeito a achados comportamentais e neurofisiológicos e sua associação com a condição clínica. Somente modelos animais específicos de esquizofrenia podem, em último caso, levar a novas abordagens diagnósticas e descoberta de drogas. Argumentamos que biomarcadores moleculares são importantes para aumentar a tradução de animais a humanos, já que faltam a especificidade e a fidelidade necessárias às leituras comportamentais para avaliar sintomas psiquiátricos humanos.

This is an open access article published under a CC-BY-NC 4.0 license.

Funders: Stanley Medical Research Institute (SMRI), European Union FP7 SchizDX research programme, NEWMEDS Innovative Medicines Initiative
Projects and Grants: 223427
Date Deposited: 17 Jul 2013 05:27
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1109 Neurosciences > 110903 Central Nervous System @ 70%
11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110319 Psychiatry (incl Psychotherapy) @ 20%
06 BIOLOGICAL SCIENCES > 0604 Genetics > 060410 Neurogenetics @ 10%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920111 Nervous System and Disorders @ 100%
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