Linkage analysis of bronchial hyperreactivity and atopy with chromosome 11q13
Wong, Zilla Y.H., Tsonis, Dina, van Herwerden, Lynne, Raven, Joan, Forbes, Andrew, Abramson, Michael J., Walters, E. Haydn, and Harrap, Stephen B. (1997) Linkage analysis of bronchial hyperreactivity and atopy with chromosome 11q13. Electrophoresis, 18 (9). pp. 1641-1645.
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Abstract
There are two key clinical features of asthma: allergy and bronchial hyperreactivity (BHR). Some pedigree studies of atopy have indicated linkage with the high affinity IgE receptor (FcϵRI-β) gene on chromosome 11q13, but others failed to confirm this linkage. We examined the genetic linkage of three polymorphic microsatellite markers to atopy and BHR in 120 affected sibling pairs recruited from the general community. We found no linkage to atopy at any of the three 11q13 loci studied. Our findings also do not favour linkage between BHR and loci approximately 8–9 cM either side of the FcϵRI-β gene.
| Item ID: | 28273 |
|---|---|
| Item Type: | Article (Research - C1) |
| ISSN: | 1522-2683 |
| Keywords: | atopy, bronchial hyperreactivity, linkage, sib-pair analysis |
| Date Deposited: | 01 Aug 2013 00:27 |
| FoR Codes: | 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110311 Medical Genetics (excl Cancer Genetics) @ 100% |
| SEO Codes: | 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920115 Respiratory System and Diseases (incl. Asthma) @ 50% 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920110 Inherited Diseases (incl. Gene Therapy) @ 50% |
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