Genetic predisposition, humans

Jordan, Margaret A., Field, Judith, Butzkueven, Helmut, and Baxter, Alan G. (2014) Genetic predisposition, humans. In: Rose, Noel R., and Mackay, Ian R., (eds.) The Autoimmune Diseases. Elsevier, Boston, MA, USA, pp. 341-364.

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Abstract

The translation from genetic knowledge to a molecular understanding of disease is contributing to the development of improved diagnostic and therapeutic products. Here, we examine the progress in molecular understanding of autoimmune disease that has been facilitated by genetic approaches, from candidate gene studies to genetic linkage and, more recently, genome-wide association studies. We concentrate primarily on progress in the genetics of type 1 diabetes, multiple sclerosis, and systemic lupus erythematosus, and draw attention to parallels and contrasts between these diseases, other autoimmune diseases, and other immune diseases. We discuss selected gene loci where functional data have contributed to our knowledge of molecular mechanisms of disease.

Item ID: 28211
Item Type: Book Chapter (Research - B1)
Keywords: type 1 diabetes; T1D; multiple sclerosis; MS; systemic lupus erythematosus; SLE; lupus; genes; gene loci; molecular mechanisms; functional data; association studies; genetic linkage analysis; genome-wide association studies
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ISBN: 978-0-12-384929-8
Funders: National Multiple Sclerosis Society (USA), Lions Clubs of Australia, Australian Research Council (ARC), National Health and Medical Research Council of Australia (NHMRC)
Date Deposited: 07 Oct 2013 23:32
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110703 Autoimmunity @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110706 Immunogenetics (incl Genetic Immunology) @ 50%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 100%
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