Plasticity is the differentiated state of CD4 T cells

Baxter, Alan G., and Jordan, Margaret A. (2013) Plasticity is the differentiated state of CD4 T cells. Cellular & Molecular Immunology, 10 (5). pp. 375-378.

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View at Publisher Website: http://dx.doi.org/10.1038/cmi.2013.29
 
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Abstract

[Extract]The recent application of targeted mutation technologies to lymphocyte fate mapping1 has facilitated the in vivo analysis of CD4 T cells subsequent to their differentiation. The fate mapping of IL17-producing cells has shown them to be responsive to environmental cues in fungal infection and central nervous system autoimmunity. Now Stockinger's group reports that many IL17-producing CD4⁺ T cells home to intestinal Peyer's patches (PP) and convert to a follicular helper T cell (TFH) phenotype, providing critical support for T-dependent IgA responses.

Item ID: 28210
Item Type: Article (Refereed Research - C1)
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ISSN: 2042-0226
Funders: .
Date Deposited: 12 Aug 2013 23:03
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110701 Allergy @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110706 Immunogenetics (incl Genetic Immunology) @ 50%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 100%
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