Iridium(III) complexes containing 1,10-phenanthroline and derivatives: synthetic, stereochemical, and structural studies, and their antimicrobial activity

Pandrala, Mallesh, Li, Fangfei, Wallace, Lynne, Steel , Peter J., Moore II, Barry, Autschbach, Jochen, Collins, J. Grant, and Keene, F. Richard (2013) Iridium(III) complexes containing 1,10-phenanthroline and derivatives: synthetic, stereochemical, and structural studies, and their antimicrobial activity. Australian Journal of Chemistry, 66 (9). pp. 1065-1073.

[img] PDF (Published Version) - Published Version
Restricted to Repository staff only

View at Publisher Website: http://dx.doi.org/10.1071/CH13264
 
14
22


Abstract

A convenient synthetic strategy is reported for the series of complexes [Ir(pp)₃]³⁺ (where pp=phen, Me₂phen and Me₄phen) through the intermediacy of the appropriate [Ir(pp)₂(CF₃SO₃)₂]⁺ species. In the case of [Ir(phen)₃]³⁺, the cationwas resolved into its enantiomeric forms, for which the absolute configurations were determined by X-ray diffraction. The availability for the first time of the CD spectra allowed comparison with computed CD spectra. Measurement of the antimicrobial activity of the [Ir(pp)₃]³⁺ species {and the [Ir(pp)₂X₂]⁺ (X=Cl⁻, CF₃SO₃⁻) precursors involved in their synthesis}, as well as cell uptake studies with the four bacterial strains S. aureus, methicillin-resistant S. aureus (MRSA), E. coli, and P. aeruginosa, indicated that they showed little activity compared with their Ru(II) analogues. The results suggest that it is unfavourable for an individual metal centre with a 3+ charge to pass across the bacterial cell membrane.

Item ID: 28136
Item Type: Article (Research - C1)
ISSN: 1445-0038
Keywords: iridium, polypyridyl, antimicrobial activity, synthesis, circular dichroism, stereochemistry, structure, computation
Funders: Australian Research Council (ARC)
Date Deposited: 21 Jul 2013 23:43
FoR Codes: 03 CHEMICAL SCIENCES > 0302 Inorganic Chemistry > 030201 Bioinorganic Chemistry @ 20%
03 CHEMICAL SCIENCES > 0302 Inorganic Chemistry > 030207 Transition Metal Chemistry @ 60%
11 MEDICAL AND HEALTH SCIENCES > 1108 Medical Microbiology > 110801 Medical Bacteriology @ 20%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970103 Expanding Knowledge in the Chemical Sciences @ 90%
97 EXPANDING KNOWLEDGE > 970111 Expanding Knowledge in the Medical and Health Sciences @ 10%
Downloads: Total: 22
More Statistics

Actions (Repository Staff Only)

Item Control Page Item Control Page