Intratracheal administration of glucocorticoids using surfactant as a vehicle

Nimmo, Alan, Carstairs, Jill R., Patole, Sanjay K., Whitehall, John, Davidson, Kate, and Vink, Robert (2002) Intratracheal administration of glucocorticoids using surfactant as a vehicle. Clinical and Experimental Pharmacology and Physiology, 29 (8). pp. 661-665.

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1. Glucocorticoids are an effective treatment in the amelioration of chronic lung disease in neonates. However, systemic administration of glucocorticoids to neonates is associated with significant side-effects that preclude them as an early intervention to prevent onset of the condition. Conversely, local intratracheal administration of glucocorticoids may prevent inflammatory insult to the lungs without the development of systemic side-effects. We therefore investigated whether local intratracheal delivery of corticosteroids could be facilitated using surfactant as a vehicle.

2. Addition of dexamethasone to either diluted or commercial artificial surfactant, Survanta (Abbott Industries, Sydney, NSW, Australia), did not alter the surface properties of the surfactant.

3. After intratracheal instillation to rats, radiolabelled dexamethasone in Survanta was well distributed throughout all four lobes of the lungs. A concentration gradient of the steroid was observed between the root and the peripheral sections of all lobes.

4. Our results suggest that surfactant is an effective vehicle for intratracheal delivery of glucocorticoids. Moreover, we propose that prophylactic intratracheal administration of glucocorticoids administered shortly after birth may prevent inflammatory insult to the lungs and thereby reduce the likelihood of chronic lung disease developing

Item ID: 27268
Item Type: Article (Research - C1)
ISSN: 1440-1681
Keywords: chronic lung disease, dexamethasone, instillation, respiratory distress syndrome
Date Deposited: 29 May 2013 05:27
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1199 Other Medical and Health Sciences > 119999 Medical and Health Sciences not elsewhere classified @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1116 Medical Physiology > 111603 Systems Physiology @ 50%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920118 Surgical Methods and Procedures @ 50%
92 HEALTH > 9299 Other Health > 929999 Health not elsewhere classified @ 50%
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