Cyclotides: macrocyclic peptides with applications in drug design and agriculture

Craik, David J., Mylne, Joshua S., and Daly, Norelle L. (2010) Cyclotides: macrocyclic peptides with applications in drug design and agriculture. Cellular and Molecular Life Sciences, 67 (1). pp. 9-16.

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Abstract

Cyclotides are disulfide-rich peptides from plants that are exceptionally stable as a result of their unique cyclic cystine knot structural motif. Their natural role is thought to be as plant defence agents, most notably against insect pests, but they also have potential applications in drug design and agriculture. This article identifies gaps in current knowledge on cyclotides and suggests future directions for research into this fascinating family of ultra-stable mini-proteins.

Item ID: 27055
Item Type: Article (Research - C1)
ISSN: 1420-9071
Keywords: circular proteins, cyclic cystine knot, cyclisation, kalata B1
Date Deposited: 07 Jun 2013 02:52
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1101 Medical Biochemistry and Metabolomics > 110106 Medical Biochemistry: Proteins and Peptides (incl Medical Proteomics) @ 100%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970111 Expanding Knowledge in the Medical and Health Sciences @ 100%
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