Total synthesis of the analgesic conotoxin MrVIB through selenocysteine-assisted folding

de Araujo, Aline Dantas, Callaghan, Brid, Nevin, Simon T., Daly, Norelle L., Craik, David J., Moretta, Melissa, Hopping, Gene, Christie, Macdonald J., Adams, David J., and Alewood, Paul F. (2011) Total synthesis of the analgesic conotoxin MrVIB through selenocysteine-assisted folding. Angewandte Chemie International Edition, 50 (29). pp. 6527-6529.

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Abstract

Secs for your folding problems: Selenocysteine (Sec) residues were used to drive the folding of conotoxin MrVIB, a previously "unfoldable" miniprotein with therapeutic potential (see picture). This simple strategy should generally facilitate the folding of peptides and proteins with multiple disulfide bonds.

Item ID: 27024
Item Type: Article (Research - C1)
ISSN: 1521-3773
Keywords: disulfides; ion channels; peptides; regioselective folding; selenocysteine
Date Deposited: 23 May 2013 04:41
FoR Codes: 03 CHEMICAL SCIENCES > 0304 Medicinal and Biomolecular Chemistry > 030401 Biologically Active Molecules @ 100%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970103 Expanding Knowledge in the Chemical Sciences @ 100%
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