Ulett, Glen C., Ketheesan, Natkunam, Clair, Timothy W., McElnea, Catriona L., Barnes, Jodie, and Hirst, Robert (2002) Analogous cytokine responses to Burkholderia pseudomallei strains contrasting in virulence correlate with partial cross-protection in immunized mice. Infection and Immunity, 70 (7). pp. 3953-3958.

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Abstract

Cytokine mRNA levels were assessed in Burkholderia pseudomallei-susceptible BALB/c mice and B. pseudomallei-resistant C57BL/6 mice following administration of a sublethal dose of less virulent (LV) B. pseudomallei, a candidate immunogen tested for protection against a highly virulent (HV) challenge. Compared on the basis of the bacterial loads, the cytokine patterns induced by HV and LV B. pseudomallei were similar, involving gamma interferon, interleukin-10, and other cytokines. Partial cross-protection between B. pseudomallei strains is shown to be associated with cytokine profiles involving both type 1 and type 2 cytokines.

Item ID:	26889
Item Type:	Article (Research - C1)
ISSN:	1098-5522
Keywords:	Burkholderia pseudomallei, cross protection, melioidosis, virulence
Date Deposited:	13 May 2013 04:40
FoR Codes:	11 MEDICAL AND HEALTH SCIENCES > 1108 Medical Microbiology > 110801 Medical Bacteriology @ 100%
SEO Codes:	92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
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