Mapping quantitative trait loci (QTL) in sheep. I: a new male framework linkage map and QTL for growth rate and body weight
Raadsma, Herman W., Thomson, Peter C., Zenger, Kyall R., Cavanagh, Colin, Lam, Mary K., Jonas, Elisabeth, Jones, Marilyn, Attard, Gina, Palmer, David, and Nicholas, Frank W. (2009) Mapping quantitative trait loci (QTL) in sheep. I: a new male framework linkage map and QTL for growth rate and body weight. Genetics Selection Evolution, 41. pp. 1-10.
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Abstract
A male sheep linkage map comprising 191 microsatellites was generated from a single family of 510 Awassi-Merino backcross progeny. Except for ovine chromosomes 1, 2, 10 and 17, all other chromosomes yielded a LOD score difference greater than 3.0 between the best and second-best map order. The map is on average 11% longer than the Sheep Linkage Map v4.7 male-specific map. This map was employed in quantitative trait loci (QTL) analyses on body-weight and growth-rate traits between birth and 98 weeks of age. A custom maximum likelihood program was developed to map QTL in half-sib families for non-inbred strains (QTL-MLE) and is freely available on request. The new analysis package offers the advantage of enabling QTL x fixed effect interactions to be included in the model. Fifty-four putative QTL were identified on nine chromosomes. Significant QTL with sex-specific effects (i.e. QTL x sex interaction) in the range of 0.4 to 0.7 SD were found on ovine chromosomes 1, 3, 6, 11, 21, 23, 24 and 26.
| Item ID: | 26716 |
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| Item Type: | Article (Research - C1) |
| ISSN: | 1297-9686 |
| Additional Information: | © 2009 Raadsma et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Funders: | Australian Research Council (ARC), Cooperative Research Centre for In novative Dairy Products |
| Date Deposited: | 24 Apr 2013 11:07 |
| FoR Codes: | 07 AGRICULTURAL AND VETERINARY SCIENCES > 0702 Animal Production > 070201 Animal Breeding @ 50% 06 BIOLOGICAL SCIENCES > 0604 Genetics > 060412 Quantitative Genetics (incl Disease and Trait Mapping Genetics) @ 50% |
| SEO Codes: | 83 ANIMAL PRODUCTION AND ANIMAL PRIMARY PRODUCTS > 8303 Livestock Raising > 830310 Sheep - Meat @ 100% |
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