Martins-Melo, Francisco Rogerlandio, Ramos Jr, Alberto Novaes, Alencar, Carlos Henrique, and Heukelbach, Jorg (2012) Mortality due to Chagas disease in Brazil from 1979 to 2009: trends and regional differences. Journal of Infection in Developing Countries, 6 (11). pp. 817-824.

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Abstract

Introduction: Studies on mortality due to parasitic diseases such as Chagas disease are useful to understand the epidemiology and to plan and guide control measures for these diseases. We analyzed mortality trends due to Chagas disease in Brazil and regions, between 1979 and 2009.

Methodology: Mortality data (underlying cause of death) were obtained from the nationwide Mortality Information System (SIM) of the Ministry of Health. We calculated crude mortality rates and rates standardized by age, as well as proportional mortality.

Results: In total, 27,560,043 deaths occurred in the study period. In 172,066 deaths, Chagas disease was mentioned as the underlying cause (proportional mortality: 0.62%). The mean crude and age-standardized mortality rates were 3.61 and 5.19 deaths/100,000 inhabitants/year, respectively. During the observation period, Chagas mortality declined significantly at the national level (R2=97%, p<0.001), with different patterns between regions. There was a significant reduction in mortality in the Central-West (R2=90%, p<0.001), Southeast (R2=98%, p<0.001) and South (R2=94%, p< 0.001), but in the North (R2=34%, p=0.001) and Northeast (R2=65%, p<0.001) regions mortality increased.

Conclusions: Despite the overall decline in mortality due to Chagas disease in Brazil, it remains an important public health problem. After successful control of the primary vector Triatoma infestans, intervention measures must focus on improved access to health care and secondary prevention. The North and Northeast regions, where vectors other than T. infestans have a primary role, need special attention.

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