Akhilesh, Meenakshi , Mahalingam, Vivekananda , Nalliah, Sivalingam, Ali, Rosalina Mohd, Murali, Ganesalingam, and Haleagrahara, Nagaraja (2013) Hypoxia-inducible factor-1α as a predictive marker in pre-eclampsia. Biomedical Reports, 1 (2). pp. 257-258.

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Abstract

The aim of this study was to determine whether or not the increased levels of hypoxia‑inducible factor‑1α (HIF-1α) could be used to demonstrate failed placentation in pre‑eclamptic mothers. Twenty pregnant females with (pre‑eclampsia group) or without pre‑eclampsia (control group) were included in the present study. Antenatal and post‑delivery HIF-1α transcription factor levels were measured. A significant increase was observed in the HIF-1α levels in the pre‑ and postnatal pre‑eclampsia mothers. The findings suggest that the levels of HIF-1α in the blood of mothers with pre‑eclampsia decrease after delivery of the placenta. The results confirm that there is increased HIF-1α in pre‑eclampsia and a steady increase in the levels of HIF-1α could be commensurate with the possibility of a patient developing pre‑eclampsia at a later trimester.

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