Effects of Etlingera elatior extracts on lead acetate-induced testicular damage: a morphological and biochemical study

Haw, Khor Yen, Chakravarthi, Srikumar, Haleagrahara, Nagaraja, and Rao, Mallikarjuna (2012) Effects of Etlingera elatior extracts on lead acetate-induced testicular damage: a morphological and biochemical study. Experimental and Therapeutic Medicine, 3 (1). pp. 99-104.

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Abstract

Lead causes damage to the whole body by inducing oxidative stress. This includes the testis, in which spermatogenesis is affected. Etlingera elatior, a consumable plant that is being extensively studied for its high anti-oxidant properties, was tested against the effect of lead acetate in experimental rats. Rats were divided into groups consisting of a control, lead acetate only, Etlingera elatior treatment only, concurrent treatment of lead acetate and Etlingera elatior, post-treatment of lead acetate followed by Etlingera elatior and preventive group of Etlingera elatior followed by lead acetate. The substances were administered for 14 days and the effects were measured by protein carbonyl content (PCC), superoxide dismutase (SOD) activity, glutathione peroxidase (GPx) activity in the testis, as well as the testosterone level in the serum. Histological changes in the testis were also observed. Results showed that Etlingera elatior induced a significant reduction in the testis PCC activity, while at the same time it significantly increased the activities of SOD and GPx in the testis, and the testosterone level in the serum. Etlingera elatior also improved the histology of the testis when compared to the lead acetate-treated group. On the whole, Etlingera elatior is effective against oxidative damage caused by lead acetate in the testis.

Item ID: 25754
Item Type: Article (Research - C1)
ISSN: 1792-1015
Keywords: Etlingera elatior, oxidative stress, spermatogenesis, testis
Funders: International Medical University, Malaysia
Date Deposited: 24 Mar 2013 23:40
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1111 Nutrition and Dietetics > 111103 Nutritional Physiology @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1104 Complementary and Alternative Medicine > 110499 Complementary and Alternative Medicine not elsewhere classified @ 50%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970111 Expanding Knowledge in the Medical and Health Sciences @ 100%
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