High in vitro efficacy of Nyda® L, a pediculicide containing dimeticone

Oliveira, F.A.S., Speare, R., and Heukelbach, J. (2007) High in vitro efficacy of Nyda® L, a pediculicide containing dimeticone. Journal of the European Academy of Dermatology and Venereology, 21 (10). pp. 1325-1329.

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Background: The therapy of pediculosis remains a common problem in clinical practice. As resistance to commonly used chemical pediculicides is constantly increasing, there is a need for new effective compounds.

Study design: The efficacy of Nyda® L, a new pediculicide containing a high concentration of dimeticone, was assessed in an in vitro trial and compared with three reference products (Hedrin® containing 4% dimeticone, Lyclear® containing 1% permethrin, and Prioderm® containing 1% malathion) and a negative control group. Head lice were collected from heavily infested patients in a resource-poor community in Northeast Brazil, where no resistance against pediculicides has been reported thus far. In each of the five groups, 50 adult fully vital lice were tested. We used a dip test (immersing head lice in the undiluted products for 3 min, washing off products after 20 min). Using predefined criteria for mortality, the lice were monitored at different points in time, for a period of 24 h.

Results: Nyda® L and Prioderm® killed all head lice already after 5 min. The efficacy of Nyda® L was better than of Lyclear®. Lice treated with Hedrin® resurrected after several hours and did not show a significantly higher mortality compared with the control group after 24 h.

Conclusion: Nyda® L can be regarded as a very efficacious pediculicidal compound, killing all lice in vitro within 5 min.

Item ID: 2553
Item Type: Article (Research - C1)
ISSN: 0926-9959
Keywords: head lice; therapy; dimeticone; NYDA C
Date Deposited: 23 Jul 2009 06:43
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1108 Medical Microbiology > 110803 Medical Parasitology @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1199 Other Medical and Health Sciences > 119999 Medical and Health Sciences not elsewhere classified @ 50%
SEO Codes: 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920408 Health Status (e.g. Indicators of Well-Being) @ 100%
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