RNA interference with special reference to combating viruses of crustacea

La Fauce, Kathy, and Owens, Leigh (2012) RNA interference with special reference to combating viruses of crustacea. Indian Journal of Virology, 23 (2). pp. 226-243.

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RNA interference has evolved from being a nuisance biological phenomenon to a valuable research tool to determine gene function and as a therapeutic agent. Since pioneering observations regarding RNA interference were first reported in the 1990s from the nematode worm, plants and Drosophila, the RNAi phenomenon has since been reported in all eukaryotic organisms investigated from protozoans, plants, arthropods, fish and mammals. The design of RNAi therapeutics has progressed rapidly to designing dsRNA that can specifically and effectively silence disease related genes. Such technology has demonstrated the effective use of short interfering as therapeutics. In the absence of a B cell lineage in arthropods, and hence no long term vaccination strategy being available, the introduction of using RNA interference in crustacea may serve as an effective control and preventative measure for viral diseases for application in aquaculture.

Item ID: 25395
Item Type: Article (Research - C1)
ISSN: 0974-0120
Keywords: RNA interference, crustacea, viruses, WSSV, YHV, TSV, PmergDNV, MrNV
Funders: Indo-Australian Biotechnology Fund
Date Deposited: 12 Mar 2013 06:41
FoR Codes: 06 BIOLOGICAL SCIENCES > 0605 Microbiology > 060506 Virology @ 50%
07 AGRICULTURAL AND VETERINARY SCIENCES > 0704 Fisheries Sciences > 070404 Fish Pests and Diseases @ 50%
SEO Codes: 83 ANIMAL PRODUCTION AND ANIMAL PRIMARY PRODUCTS > 8301 Fisheries - Aquaculture > 830105 Aquaculture Prawns @ 100%
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