Colostrum supplementation protects against exercise - induced oxidative stress in skeletal muscle in mice

Appukutty, Mahenderan, Radhakrishnan, Ammu Kutty, Ramasamy, Kalavathy, Ramasamy, Rajesh, Abdul Majeed, Abu Bakar, Ismail Noor, Mohd, Shanita Safii, Nik, Bee Koon, Poh, Chinna, Karuthan, and Nagaraja, Haleagrahara (2012) Colostrum supplementation protects against exercise - induced oxidative stress in skeletal muscle in mice. BMC Research Notes, 5. 649. pp. 1-8.

[img]
Preview
PDF (Published Version) - Published Version
Available under License Creative Commons Attribution.

Download (214kB)
View at Publisher Website: http://dx.doi.org/10.1186/1756-0500-5-64...
 
7
82


Abstract

Background: This study examined the effects of bovine colostrum on exercise –induced modulation of antioxidant parameters in skeletal muscle in mice. Adult male BALB/c mice were randomly divided into four groups (control, colostrum alone, exercise and exercise with colostrum) and each group had three subgroups (day 0, 21 and 42). Colostrum groups of mice were given a daily oral supplement of 50 mg/kg body weight of bovine colostrum and the exercise group of mice were made to exercise on the treadmill for 30 minutes per day. Total antioxidants, lipid hydroperoxides, xanthine oxidase and super oxide dismutase level was assayed from the homogenate of hind limb skeletal muscle.

Results: Exercise—induced a significant oxidative stress in skeletal muscles as evidenced by the elevated lipid hydroperoxides and xanthine oxidase levels. There was a significant decrease in skeletal muscle total antioxidants and superoxide dismutase levels. Daily colostrum supplement significantly reduced the lipid hydroperoxides and xanthine oxidase enzyme level and increased the total antioxidant levels in the leg muscle.

Conclusion: Thus, the findings of this study showed that daily bovine colostrum supplementation was beneficial to skeletal muscle to reduce the oxidant-induced damage during muscular exercise.

Item ID: 25353
Item Type: Article (Research - C1)
ISSN: 1756-0500
Keywords: bovine colostrum, exercise, skeletal muscle, antioxidants, lipid hydroperoxides
Date Deposited: 11 Mar 2013 05:20
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1111 Nutrition and Dietetics > 111103 Nutritional Physiology @ 25%
11 MEDICAL AND HEALTH SCIENCES > 1106 Human Movement and Sports Science > 110602 Exercise Physiology @ 65%
11 MEDICAL AND HEALTH SCIENCES > 1116 Medical Physiology > 111603 Systems Physiology @ 10%
SEO Codes: 92 HEALTH > 9299 Other Health > 929999 Health not elsewhere classified @ 100%
Downloads: Total: 82
Last 12 Months: 19
More Statistics

Actions (Repository Staff Only)

Item Control Page Item Control Page