Wernicke's encephalopathy mimicking variant Creutzfeldt-Jakob disease

Stone, Richard, Archer, John, and Kiernan, Matthew (2008) Wernicke's encephalopathy mimicking variant Creutzfeldt-Jakob disease. Journal of Clinical Neuroscience, 15 (11). pp. 1308-1310.

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A 45-year-old man from tropical Australia was admitted with subacute social withdrawal, cognitive deterioration, reduced awareness and eventual mutism. Variant Creutzfeldt-Jakob disease was considered on the basis of WHO case definition criteria including typical clinical features and MRI showing symmetrical hyperintensity in the pulvinar (posterior) nuclei of the thalami. However, tonsillar biopsy was negative. Wernicke's encephalopathy was established on the basis of low serum thiamine on admission and eventual clinical improvement on high-dose intravenous thiamine replacement, despite initial failure to respond to the standard dose of 100 mg daily intramuscularly.

Item ID: 25286
Item Type: Article (Case Study)
ISSN: 1532-2653
Keywords: Wrnicke, thiamine, variant Creutzfeld Jacob Disease
Date Deposited: 05 Mar 2013 04:47
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1109 Neurosciences > 110904 Neurology and Neuromuscular Diseases @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920111 Nervous System and Disorders @ 100%
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