Determining the crystal purity of mebendazole raw material and stability in suspension by DRA-UV-spectroscopy, ATR-FTIR spectroscopy and ANN spectral modelling

Agatonovic-Kustrin, S., Glass, B.D., Mangan, M., and Smithson, John (2008) Determining the crystal purity of mebendazole raw material and stability in suspension by DRA-UV-spectroscopy, ATR-FTIR spectroscopy and ANN spectral modelling. Farmacevtski Vestnik, 59. pp. 54-55.

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Abstract

[Extract] Mebendazole, methyl 5-benzoyl benzimidazole-2-carbamate, a broadspectrum anthelmintic drug exists in three polymorphic forms (A, B, C) with different solubilities and thermodynamic stabilities [1]. Due to its poor solubility, the more soluble, but less stable Form C is therapeutically favoured in drug formulations such as suspensions [2]. The objectives of this work were to develop simple, direct and non-destructive procedures to identify and quantify crystal purity of mebendazole raw material and to establish stability of the preferred Form C in a suspension formulation.

Item ID: 25247
Item Type: Article (Abstract)
Keywords: mebendazole, DRA-UV-spectroscopy, ATR-FTIR spectroscopy
Additional Information:

Special Issue- Proceedings of the 7th Central European Symposium on Pharmaceutical Technology and Systems Biodelivery

ISSN: 0014-8229
Date Deposited: 05 Mar 2013 01:35
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9299 Other Health > 929999 Health not elsewhere classified @ 100%
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