Remarkable in vitro bactericidal activity of bismuth(iii) sulfonates against Helicobacter pylori

Andrews, Philip C., Busse, Madleen, Deacon, Glen B., Ferrero, Richard L., Junk, Peter C., MacLellan, Jonathan G., and Vom, Amelia (2012) Remarkable in vitro bactericidal activity of bismuth(iii) sulfonates against Helicobacter pylori. Dalton Transactions, 41 (38). pp. 11798-11806.

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Abstract

Four new tris-substituted bismuth(III) sulfonates of general formula [Bi(O3SR)3] (R = phenyl 1, p-tolyl 2, 2,4,6-mesityl 3 and S-(+)-10-camphoryl 4) have been synthesised and characterised. Their synthesis by solvent-free (SF) and solvent-mediated (SM) methods has been explored and their activity against Helicobacter pylori has been investigated. The compounds 1–4 display a remarkable in vitro activity against three laboratory strains of H. pylori (B128, 26 695 and 251) with minimum inhibitory concentration (MIC) values as low as 0.049 μg mL−1 for the strains B128 and 26 695, and 0.781 μg mL⁻¹ for the clinical isolate 251. This places most MIC values in the nano-molar region and demonstrates the strong influence of the sulfonate group on the bactericidal properties. The novel solid state structure [Bi₈(O₃SMes)₂₀(SO₄)₂(H₂O)₆]·(C₇H₈)₇₅·(C₇H₈)₇, derived from the SM reaction under reflux conditions, is presented and the incorporation of the two inorganic sulfate anions in the centre of the wheel-like bismuth sulfonate cluster explained.

Item ID: 25243
Item Type: Article (Refereed Research - C1)
ISSN: 1477-9234
Date Deposited: 23 Apr 2013 05:42
FoR Codes: 03 CHEMICAL SCIENCES > 0302 Inorganic Chemistry > 030202 f-Block Chemistry @ 100%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970103 Expanding Knowledge in the Chemical Sciences @ 100%
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