Severe systemic lupus erythematosus induced by antiviral treatment for hepatitis C

Ho, Vincent, Mclean, Anna, and Terry, Shaughan (2008) Severe systemic lupus erythematosus induced by antiviral treatment for hepatitis C. Journal of Clinical Rheumatology, 14 (3). pp. 166-168.

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Abstract

We report the case of a 43-year-old man who developed systemic lupus erythematosus (SLE) after receiving pegylated [alpha]-interferon and ribavirin for chronic hepatitis C. He displayed 8 features of the American College of Rheumatology criteria for SLE: glomerulonephritis, arthritis, serositis, a florid discoid rash, lymphopenia, oral ulcers, the development of high titers of antinuclear antibodies, and antidouble stranded DNA antibodies. Furthermore, his admission was complicated by the development of life threatening myopericarditis and vasculitis. This case is notable for the clinical severity and nature of multiorgan lupus involvement from hepatitis C antiviral therapy. Clinical signs of SLE have resolved and anti DS DNA has normalized.

Item ID: 25234
Item Type: Article (Case Study)
ISSN: 1076-1608
Keywords: hepatitis C, lupus, interferon, antivirals, autoimmune
Date Deposited: 04 Mar 2013 06:27
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110307 Gastroenterology and Hepatology @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110309 Infectious Diseases @ 50%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
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