Cholestatic hepatitis as a possible new side-effect of oxycodone: a case report

Ho, Vincent, Stewart, Maxwell, and Boyd, Peter (2008) Cholestatic hepatitis as a possible new side-effect of oxycodone: a case report. Journal of Medical Case Reports, 2 (140). pp. 1-4.

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Abstract

Introduction: Oxycodone is a widely-used semisynthetic opioid analgesic that has been used for over eighty years. Oxycodone is known to cause side effects such as nausea, pruritus, dizziness, constipation and somnolence. As far as we are aware cholestatic hepatitis as a result of oxycodone use has not been reported so far in the world literature.

Case presentation: A 34-year-old male presented with cholestatic jaundice and severe pruritus after receiving oxycodone for analgesia post-T11 vertebrectomy. Extensive laboratory investigations and imaging studies did not reveal any other obvious cause for his jaundice and a liver biopsy confirmed canalicular cholestatis suggestive of drug-induced hepatotoxicity. The patient's symptoms and transaminases normalised on withdrawal of oxycodone confirming that oxycodone was the probable cause of the patient's hepatotoxicity.

Conclusion: We conclude that cholestatic hepatitis is possibly a rare side effect of oxycodone use. Physicians should be aware of the possibility of this potentially serious picture of drug-induced hepatotoxicity.

Item ID: 25230
Item Type: Article (Case Study)
ISSN: 1752-1947
Keywords: oxycodone side effects, hepatic injury, cholestatic hepatitis
Date Deposited: 04 Mar 2013 05:51
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110307 Gastroenterology and Hepatology @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920105 Digestive System Disorders @ 100%
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