Hyperpigmentation, nail dystrophy and alopecia with generalised intestinal polyposis: Cronkhite–Canada syndrome

Ho, Vincent, Banney, Leith, and Falhammar, Henrik (2008) Hyperpigmentation, nail dystrophy and alopecia with generalised intestinal polyposis: Cronkhite–Canada syndrome. Australasian Journal of Dermatology, 49 (4). pp. 223-225.

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Abstract

A 62-year-old Malaysian woman presented with a constellation of skin signs including alopecia, hyperpigmentation and nail dystrophy. On questioning, a history of diarrhoea, taste disturbance and weight loss was found. The onset of these changes coincided with the administration of thyroxine prescribed for a benign multinodular goitre. Hormonal investigations showed no abnormality and no underlying malignancy was found. Investigation of the diarrhoea showed a protein-losing enteropathy with generalized intestinal polyposis and non-specific histology. A diagnosis of Cronkhite–Canada syndrome was made. Treatment with prednisone and nutritional support has been partially effective.

Item ID: 25229
Item Type: Article (Case Study)
ISSN: 1440-0960
Keywords: benign multinodular goitre, diarrhoea, goitre, hypogeusia, prednisone, protein-losing enteropathy
Date Deposited: 04 Mar 2013 05:43
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110304 Dermatology @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110307 Gastroenterology and Hepatology @ 50%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920117 Skin and Related Disorders @ 100%
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