Antioxidant and anti-inflammatory activities of selected Chinese medicinal plants and their relation with antioxidant content

Ravipati, Anjaneya S., Zhang, Lin, Koyyalamudi, Sundar Rao, Jeong, Sang Chul, Reddy, Narsimha, Bartlett, John, Smith, Paul T., Shanmugam, Kirubakaran, Münch, Gerald, Wu, Ming Jie, Satyanarayanan, Manavalan, and Vysetti, Balaram (2012) Antioxidant and anti-inflammatory activities of selected Chinese medicinal plants and their relation with antioxidant content. BMC Complementary and Alternative Medicine, 12. 173. pp. 1-14.

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Background: The main aim of this study is to evaluate the antioxidant and anti-inflammatory properties of forty four traditional Chinese medicinal herbal extracts and to examine these activities in relation to their antioxidant content.

Methods: The antioxidant activities were investigated using DPPH radical scavenging method and yeast model. The anti-inflammatory properties of the herbal extracts were evaluated by measuring their ability to inhibit the production of nitric oxide and TNF-alpha in RAW 264.7 macrophages activated by LPS and IFN-gamma, respectively. The cytotoxic effects of the herbal extracts were determined by Alomar Blue assay by measuring cell viability. In order to understand the variation of antioxidant activities of herbal extracts with their antioxidant contents, the total phenolics, total flavonoids and trace metal (Mg, Mn, Cu, Zn, Se and Mo) quantities were estimated and a correlation analysis was carried out.

Results: Results of this study show that significant levels of phenolics, flavonoids and trace metal contents were found in Ligustrum lucidum, Paeonia suffuticosa, Salvia miltiorrhiza, Sanguisorba officinalis, Spatholobus suberectus, Tussilago farfara and Uncaria rhyncophylla, which correlated well with their antioxidant and anti-inflammatory activities. Some of the plants displayed high antioxidant and anti-inflammatory activities but contained low levels of phenolics and flavonoids. Interestingly, these plants contained significant levels of trace metals (such as Zn, Mg and Se) which are likely to be responsible for their activities.

Conclusions: The results indicate that the phenolics, flavonoids and trace metals play an important role in the antioxidant activities of medicinal plants. Many of the plants studied here have been identified as potential sources of new antioxidant compounds.

Item ID: 25053
Item Type: Article (Research - C1)
ISSN: 1472-6882
Keywords: antioxidant activities, anti-inflammatory properties, phenolics, flavonoids, trace metals
Date Deposited: 20 Feb 2013 09:16
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1104 Complementary and Alternative Medicine > 110404 Traditional Chinese Medicine and Treatments @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified @ 50%
SEO Codes: 92 HEALTH > 9299 Other Health > 929999 Health not elsewhere classified @ 50%
97 EXPANDING KNOWLEDGE > 970111 Expanding Knowledge in the Medical and Health Sciences @ 50%
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