Angiotensin converting enzyme 2 and atherosclerosis

Wang, Yutang, Tikellis, Chris, Thomas, Merlin C., and Golledge, Jonathan (2013) Angiotensin converting enzyme 2 and atherosclerosis. Atherosclerosis, 226 (1). pp. 3-8.

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Abstract

Angiotensin converting enzyme 2 (ACE2) is a homolog of angiotensin converting enzyme (ACE) which generates angiotensin II from angiotensin I. ACE, its product angiotensin II and the downstream angiotensin type I receptor are important components of the renin-angiotensin system (RAS). Angiotensin II, the most important component of the RAS, promotes the development of atherosclerosis. The identification of ACE2 in 2000 opened a new chapter of research on the regulation of the RAS. ACE2 degrades pro-atherosclerotic angiotensin II and generates anti-atherosclerotic angiotensin 1-7. In this review, we explored the importance of ACE2 in protecting experimental animals from developing atherosclerosis and its involvement in human atherosclerosis. We also examined the published evidence assessing the importance of ACE2 in different cell types relevant to atherosclerosis and putative underlying cellular and molecular mechanisms linking ACE2 with protection from atherosclerosis. ACE2 shifts the balance from angiotensin II to angiotensin 1-7 inhibiting the progression of atherosclerosis in animal models.

Item ID: 25039
Item Type: Article (Research - C1)
ISSN: 1879-1484
Keywords: angiotensin 1-7, angiotensin II, angiotensin converting enzyme 2, atherosclerosis, renin-angiotensin system
Funders: National Institute of Allergy and Infectious Disease (NIAID)
Projects and Grants: 540404/1021416
Date Deposited: 20 Feb 2013 09:20
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl Cardiovascular Diseases) @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 100%
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