Soluble fms-like tyrosine kinase-1 (sFLT-1) predicts post-percutaneous coronary intervention (PCI) myocardial infarction (MI type 4a)
Searle, Julia, Slagman, Anna, Gwosc, Stefanie, Vollert, Jorn Ole, Holert, Fabian, Mueller, Christian, Muller, Reinhold, and Moeckel, Martin (2012) Soluble fms-like tyrosine kinase-1 (sFLT-1) predicts post-percutaneous coronary intervention (PCI) myocardial infarction (MI type 4a). Biomarkers, 17 (8). pp. 730-737.
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Abstract
Context: Acute myocardial infarction (AMI) related to percutaneous coronary intervention (PCI) (MI type 4a) occurs in up to 26% of elective patients.
Objective: To evaluate if sFLT-1 helps to predict MI type 4a in troponin negative patients with elective PCI.
Materials and methods: We enrolled 135 patients, 106 had a PCI. sFLT-1 levels were assessed at five time points before and after PCI.
Results: MI type 4a occurred in 22.1% of patients. sFLT-1 levels at admission above 251 pg/mL indicated a significant relative risk for MI type 4a of 2.83.
Conclusion and discussion: Increased sFLT-1 levels at baseline might indicate unstable atherosclerosis and risk for microembolization and thus be predictive of MI type 4a.
Item ID: | 24544 |
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Item Type: | Article (Research - C1) |
ISSN: | 1366-5804 |
Keywords: | cardiovascular disease, growth factors/cytokines/inflammatory mediators |
Funders: | Abbott Laboratories |
Date Deposited: | 09 Jan 2013 05:35 |
FoR Codes: | 11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111799 Public Health and Health Services not elsewhere classified @ 100% |
SEO Codes: | 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920499 Public Health (excl. Specific Population Health) not elsewhere classified @ 100% |
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