The tumorigenic liver fluke Opisthorchis viverrini - multiple pathways to cancer

Sripa, Banchob, Brindley, Paul J., Mulvenna, Jason, Laha, Thewarach, Smout, Michael J., Mairiang, Eimorn, Bethony, Jeffrey M., and Loukas, Alex (2012) The tumorigenic liver fluke Opisthorchis viverrini - multiple pathways to cancer. Trends in Parasitology, 28 (10). pp. 395-407.

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Abstract

Liver fluke infection caused by Opisthorchis viverrini is a major public health problem in Thailand and adjacent countries. In addition to infection-associated morbidity, infection with O. viverrini and the related Clonorchis sinensis are unarguable risk factors for cholangiocarcinoma (CAA, bile-duct cancer). Here we review the pathogenesis of opisthorchiasis and the association between O. viverrini infection and bile-duct cancer, focusing on the molecular parallels between wound healing, chronic inflammation, and cancer development. We review a schema for human disease progression from fluke infection, chronic opisthorchiasis, advanced periductal fibrosis, and cholangiocarcinogenesis, and present a rationale for biomarker discovery to facilitate early intervention. We conclude by addressing post-genomic advances with a view to developing new control strategies to combat this infectious cancer.

Item ID: 24163
Item Type: Article (Research - C1)
ISSN: 1471-5007
Keywords: opisthorchis, liver fluke, cholangiocarcinoma, liver cancer, granulin, periductal fibrosis, excretory/secretory, wound healing
Funders: National Institute of Allergy and Infectious Disease (NIAID), National Cancer Institute (NCI), National Health and Medical Research Council of Australia (NHMRC)
Date Deposited: 05 Dec 2012 05:25
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1108 Medical Microbiology > 110803 Medical Parasitology @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 20%
92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 80%
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