Golledge, Jonathan, Parr, Adam, McCann, Moira, Buttner, Petra, Bradshaw, Barbara, and UNSPECIFIED (2010) Thrombus volume is associated with cardiovascular events and aneurysm growth in patients who have abdominal aortic aneurysms. In: Journal of Vascular Surgery (51) SS26. 17S-17S. From: Vascular Annual Meeting of the Society for Vascular Surgery, 10-13 June 2010, Boston, MA, USA.

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Abstract

Objectives: The aims of this study were to prospectively assess the association of infra-renal abdominal aortic thrombus volume with cardiovascular events and abdominal aortic aneurysm (AAA) growth.

Methods: 98 patients with AAAs (median diameter 47.2 mm) underwent computed tomography angiography (CTA). The volume of thrombus in the infra-renal aorta was measured by a previously validated technique. Patients were followed prospectively for a median of 3 (inter-quartile range 2.0-3.6) years and cardiovascular events (nonfatal stroke, nonfatal myocardial infarction, coronary revascularization, amputation and cardiovascular death) recorded. 39 patients underwent repeat CTA a median of 1.5 (inter-quartile range 1.1-3.3) years later. Kaplan-Meier and Cox-proportional analysis were used to examine the association of aortic thrombus with cardiovascular events and average weighted AAA growth.

Results: A total of 28 cardiovascular event occurred during follow-up. The incidence of cardiovascular events was 23.4 and 49.2% for patients with small (< median) and large (≥median) volumes of aortic thrombus, respectively, at 4 years (p < 0.05). AAA thrombus volume ≥median was associated with increased cardiovascular events (RR 2.8, 95% CI 1.01- 5.24) independent of other risk factors including initial aortic diameter. In the sub-set of patients with CTA follow-up median annual increase in AAA volume was 5.1cm3 (inter-quartile range 0.8-10.3). Annual abdominal aortic volume change was positively correlated with maximal axial abdominal aortic diameter (r = 0.44, p = 0.006) and thrombus volume (r = 0.50, p = 0.001). Thrombus volume ≥median was associated with rapid volumetric growth (≥5 cm3/year), independent of initial aortic diameter (OR 15.0, 95% CI 1.9-115.7, p = 0.009).

Conclusions: AAA thrombus volume was independently associated with cardiovascular events and AAA progression. The mechanisms underlying these associations warrant further study in order to determine if anti-thrombotic therapies reduce outcome events.

Item ID:	23827
Item Type:	Conference Item (Abstract / Summary)
ISSN:	1097-6809
Additional Information:	Published in Journal of Vascular Surgery, Volume 51, Issue 6, Supplement, Page 17S, June 2010.
Date Deposited:	31 Oct 2012 05:29
FoR Codes:	11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl Cardiovascular Diseases) @ 100%
SEO Codes:	92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 100%
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