Metachronous carcinomas in colorectum and its clinicopathological significance

Lam, Alfred King-Yin, Gopalan, Vinod, Carmichael, Robert, Buettner, Petra Gertraud, Leung, Melissa, Smith, Robert, Lu, Cu-Tai, Ho, Yik-Hong, and Siu, Simon (2012) Metachronous carcinomas in colorectum and its clinicopathological significance. International Journal of Colorectal Disease, 27 (10). pp. 1303-1310.

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Abstract

Purpose: The study was designed to examine the significance of colorectal metachronous carcinoma in a large cohort of patients.

Methods: Over a mean follow-up period of 10 years, the clinicopathological features, microsatellite instability (MSI) and clinical follow-up of 56 patients with metachronous colorectal carcinoma were analysed.

Results: The prevalence of metachronous colorectal carcinoma was 2.1 %. The metachronous colorectal carcinomas appeared between 7 and 246 months (mean = 66 months) after surgical resection of the index colorectal carcinomas. Thirty-six per cent (n = 20) of the metachronous carcinoma occurred more than 5 years after the operation of the index carcinoma. Of the 56 patients, 20 % (n = 11) of the metachronous colorectal carcinomas were mucinous adenocarcinoma. Cancers detected in the secondary operations (metachronous colorectal carcinomas), when compared with the primary index cancers, were smaller, showed higher proportions of mucinous adenocarcinoma and more often located in the proximal colon. Patients with metachronous colorectal cancers had higher prevalence of mucinous adenocarcinoma, loss of staining for MSI markers and better survival rates than other patients with colorectal cancers.

Conclusions: Patients with metachronous colorectal carcinomas have characteristic features, and attention to these features is important for better management of this group of cancer.

Item ID: 23826
Item Type: Article (Refereed Research - C1)
Keywords: metachronous, multiple, colorectal, cancer, carcinoma
ISSN: 1432-1262
Date Deposited: 31 Oct 2012 05:29
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110323 Surgery @ 30%
11 MEDICAL AND HEALTH SCIENCES > 1112 Oncology and Carcinogenesis > 111299 Oncology and Carcinogenesis not elsewhere classified @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111706 Epidemiology @ 20%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920102 Cancer and Related Disorders @ 100%
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