Cardiotoxic effects of venom fractions from the Australian box jellyfish Chironex fleckeri on human myocardiocytes

Saggiomo, Silvia L.A., and Seymour, Jamie E. (2012) Cardiotoxic effects of venom fractions from the Australian box jellyfish Chironex fleckeri on human myocardiocytes. Toxicon, 60 (3). pp. 391-395.

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Abstract

An investigation into the cardiotoxic effects in human cardiomyocytes of different fractions (as produced from an FPLC) of the venom from Chironex fleckeri showed that whole venom caused cardiac cell death in minutes, measured as cell detachment using xCELLigence technology. However, only one fraction of the venom was responsible for this effect. When all extracted venoms were recombined a similar result was seen for the toxic fraction, however these effects were slower than unfractionated venom alone even though the concentrations were similar. The difference in the results between fractioned and unfractionated venom may have been caused by compounds remaining in the FPLC column, which may interact with the toxic fraction to cause rapid cell detachment or death.

Item ID: 23582
Item Type: Article (Research - C1)
ISSN: 1879-3150
Keywords: human cardiomyocytes, venom, xCELLigence, Chironex fleckeri
Funders: Queensland Emergency Research Foundation
Date Deposited: 03 Oct 2012 05:44
FoR Codes: 06 BIOLOGICAL SCIENCES > 0602 Ecology > 060205 Marine and Estuarine Ecology (incl Marine Ichthyology) @ 100%
SEO Codes: 96 ENVIRONMENT > 9699 Other Environment > 969902 Marine Oceanic Processes (excl. Climate Related) @ 100%
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