Calcific uremic arteriolopathy on multimodal combination therapy: still unmet goal

Malabu, Usman, Manickam, Valli, Kan, George, Doherty, Susan Lynette, and Sangla, Kunwarjit Singh (2012) Calcific uremic arteriolopathy on multimodal combination therapy: still unmet goal. International Journal of Nephrology, 2012. 390768. pp. 1-6.

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Background: Calcific uremic arteriolopathy (CUA) or calciphylaxis though generally noted for its high mortality, recent case reports have shown promising results using single agent therapies. However, it is not clear whether combination therapeutic agents will improve course of the disease.

Objective: To determine clinical outcome in subjects with CUA on multimodal treatment. Methods. All patients with end-stage renal failure (ESRF) at The Townsville Hospital, Australia, from April 1, 2006, to March 31, 2011, with diagnosis of CUA were retrospectively studied.

Results: Six subjects with CUA (4 females and 2 males) were on various combination therapeutic agents comprising sodium thiosulphate, hyperbaric oxygen, prednisolone, cinacalcet, and parathyroidectomy in addition to intensified haemodialysis, specialist local wound care, and antibiotics. The wounds failed to heal in 3 patients while 5 of the 6 subjects died; cause of death being sepsis in 3 and myocardial infarction in 2.

Conclusion: Prognosis of CUA remains poor in spite of multimodal combination therapy. Further prospective studies on a larger population are needed to verify our findings.

Item ID: 23500
Item Type: Article (Research - C1)
ISSN: 2090-2158
Date Deposited: 08 Oct 2012 02:04
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110306 Endocrinology @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920104 Diabetes @ 100%
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