Principles of therapeutic drug monitoring: a case of drug-resistant epilepsy in a dog

Kinobe, Robert, and Keller, Ninette (2011) Principles of therapeutic drug monitoring: a case of drug-resistant epilepsy in a dog. In: Chapter of Veterinary Pharmacology Science Week 2011 Session Proceedings. pp. 37-42. From: Chapter of Veterinary Pharmacology, Science Week 2011, 2nd July 2011, Gold Coast, Queensland.

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Abstract

Drug analysis for purposes of monitoring therapeutic outcomes is not a common practice in veterinary medicine but may be extremely valuable in many circumstances including; clinical cases in which there is a poor correlation between dose and drug plasma concentration, and therapeutic or toxic effects, confirmation of drug-induced toxicity for medications with very low therapeutic indices, assessment of compliance with the drug administration and assessing the occurrence of drug-drug interactions. Therapeutic drug monitoring may also be indicated for patients with altered physiological states such as renal, thyroid and hepatic disease, and electrolyte imbalances. In this article, a clinical case of canine idiopathic epilepsy with an apparent resistance to antiepileptic drug therapy is used to illustrate some of the basic principles of therapeutic drug monitoring (TMD).

Item ID: 23372
Item Type: Conference Item (Non-Refereed Research Paper)
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Date Deposited: 20 Dec 2012 00:34
FoR Codes: 07 AGRICULTURAL AND VETERINARY SCIENCES > 0707 Veterinary Sciences > 070706 Veterinary Medicine @ 50%
07 AGRICULTURAL AND VETERINARY SCIENCES > 0707 Veterinary Sciences > 070710 Veterinary Pharmacology @ 50%
SEO Codes: 92 HEALTH > 9299 Other Health > 929999 Health not elsewhere classified @ 100%
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