Interleukin-6 gene (IL-6): a possible role in brain morphology in the healthy adult brain

Baune, Bernhard T., Konrad, Carsten, Grotegerd, Dominik, Suslow, Thomas, Birosova, Eva, Ohrmann, Patricia, Bauer, Jochen, Arolt, Volker, Heindel, Walter, Domschke, Katharina, Schoening, Sonja, Rauch, Astrid V., Uhlmann, Christina, Kugel, Harald, and Dannlowski, Udo (2012) Interleukin-6 gene (IL-6): a possible role in brain morphology in the healthy adult brain. Journal of Neuroinflammation, 9 (1). pp. 1-9.

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Abstract

Background: Cytokines such as interleukin 6 (IL-6) have been implicated in dual functions in neuropsychiatric disorders. Little is known about the genetic predisposition to neurodegenerative and neuroproliferative properties of cytokine genes. In this study the potential dual role of several IL-6 polymorphisms in brain morphology is investigated.

Methodology: In a large sample of healthy individuals (N = 303), associations between genetic variants of IL-6 (rs1800795; rs1800796, rs2069833, rs2069840) and brain volume (gray matter volume) were analyzed using voxel-based morphometry (VBM). Selection of single nucleotide polymorphisms (SNPs) followed a tagging SNP approach (e. g., Stampa algorigthm), yielding a capture 97.08% of the variation in the IL-6 gene using four tagging SNPs. Principal findings/results In a whole-brain analysis, the polymorphism rs1800795 (-174 C/G) showed a strong main effect of genotype (43 CC vs. 150 CG vs. 100 GG; x = 24, y = -10, z = -15; F(2,286) = 8.54, p(uncorrected) = 0.0002; p(AlphaSim-corrected) = 0.002; cluster size k = 577) within the right hippocampus head. Homozygous carriers of the G-allele had significantly larger hippocampus gray matter volumes compared to heterozygous subjects. None of the other investigated SNPs showed a significant association with grey matter volume in whole-brain analyses.

Conclusions/significance: These findings suggest a possible neuroprotective role of the G-allele of the SNP rs1800795 on hippocampal volumes. Studies on the role of this SNP in psychiatric populations and especially in those with an affected hippocampus (e.g., by maltreatment, stress) are warranted.

Item ID: 23186
Item Type: Article (Refereed Research - C1)
Keywords: genetics, inflammation, interleukin 6, neuroprotection, voxel-based morphometry
ISSN: 1742-2094
Funders: Medical Faculty of Münster
Date Deposited: 22 Aug 2012 05:26
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1109 Neurosciences > 110999 Neurosciences not elsewhere classified @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1101 Medical Biochemistry and Metabolomics > 110106 Medical Biochemistry: Proteins and Peptides (incl Medical Proteomics) @ 50%
SEO Codes: 92 HEALTH > 9299 Other Health > 929999 Health not elsewhere classified @ 100%
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