Surgical applications of cyanoacrylate adhesives: a review of toxicity

Leggat, Peter A., Smith, Derek R., and Kedjarune, Ureporn (2007) Surgical applications of cyanoacrylate adhesives: a review of toxicity. ANZ Journal of Surgery, 77 (4). pp. 209-213.

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Abstract

Cyanoacrylate (CA) and its homologues have a variety of medical and commercial applications as biological adhesives and sealants. Homologues of CA are being widely promoted in surgery as a tissue adhesive to replace traditional suturing techniques. Potential benefits of using CA adhesives include better cosmetic results, more rapid wound closure, and perhaps most significantly, the potential for significant reductions in percutaneous injuries from suture needles, which would in turn also reduce the risk of transmission of infectious diseases. Nevertheless, certain concerns have been raised regarding the potential toxicity of CA within patients, as well as among health professionals who are occupationally exposed when using CA compounds. Reported toxicity of CA in the workplace may result in dermatological, allergic and respiratory conditions. To help reduce the occupational burden, therefore, medical staff using CA adhesives should avoid direct contact with the compound and use appropriate personal protective measures at all times. Maintaining higher levels of humidity, optimizing room ventilation and using special air conditioning filters in surgical suites and operating theatres may also be useful in minimizing the exposure to volatile CA adhesives.

Item ID: 2314
Item Type: Article (Refereed Research - C1)
Keywords: hand dermatitis; Australia; medical students; tropical; cyanoacrylate; medical; occupational allergy; occupational asthma; occupational skin disease; surgery; toxic effect
ISSN: 1445-2197
Date Deposited: 09 Jun 2009 06:32
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111706 Epidemiology @ 100%
SEO Codes: 92 HEALTH > 9299 Other Health > 929999 Health not elsewhere classified @ 100%
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