Ianthellamide A, a selective kynurenine-3-hydroxylase inhibitor from the Australian marine sponge Ianthella quadrangulata
Feng, Yunjiang, Bowden, Bruce F., and Kapoor, Vimal (2012) Ianthellamide A, a selective kynurenine-3-hydroxylase inhibitor from the Australian marine sponge Ianthella quadrangulata. Bioorganic and Medicinal Chemistry Letters, 22 (10). pp. 3398-3401.
![[img]](https://researchonline.jcu.edu.au/style/images/fileicons/application_pdf.png) |
PDF (Published Version)
- Published Version
Restricted to Repository staff only |
Abstract
Ianthellamide A (1), a novel octopamine derivative, was isolated from the Australian marine sponge Ianthella quadrangulata. Compound 1 selectively inhibited the activity of kynurenine 3-hydroxylase with an IC50 value of 1.5 mu M. It also significantly increased the level of endogenous kynurenic acid in rat brain and hence has the potential as a neuroprotective agent in the treatment of neurodegenerative disorders.
| Item ID: | 22695 |
|---|---|
| Item Type: | Article (Research - C1) |
| ISSN: | 1464-3405 |
| Keywords: | Ianthellamide A, Kynurenine-3-hydroxylase, Kynurenine pathway |
| Funders: | Australian Research Council (ARC) |
| Date Deposited: | 01 Aug 2012 09:47 |
| FoR Codes: | 03 CHEMICAL SCIENCES > 0305 Organic Chemistry > 030502 Natural Products Chemistry @ 50% 03 CHEMICAL SCIENCES > 0304 Medicinal and Biomolecular Chemistry > 030401 Biologically Active Molecules @ 40% 06 BIOLOGICAL SCIENCES > 0601 Biochemistry and Cell Biology > 060107 Enzymes @ 10% |
| SEO Codes: | 97 EXPANDING KNOWLEDGE > 970103 Expanding Knowledge in the Chemical Sciences @ 100% |
| Downloads: |
Total: 2 |
| More Statistics |
Actions (Repository Staff Only)
 |
Item Control Page |