Analysis of p15ⁱⁿᵏ⁴ᵇ and p16ⁱⁿᵏ⁴ᵃ gene methylation in patients with oral squamous cell carcinoma

Kordi-Tamandani, Dor Mohammad, Ladies, Mohammad Ayub Rigi, Hashemi, Mohammad, Moazeni-Roodi, Abdul-Karim, Krishna, Smriti, and Torkamanzehi, Adam (2012) Analysis of p15ⁱⁿᵏ⁴ᵇ and p16ⁱⁿᵏ⁴ᵃ gene methylation in patients with oral squamous cell carcinoma. Biochemical Genetics, 50 (5-6). pp. 448-453.

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Abstract

[Extract] Cancer is the third leading cause of death in Iran, after coronary heart disease and accidents (Mousavi and Somi 2009). Apart from alterations in the various cellular oncogenes, dysregulation of tumour suppressor genes is an important event in the pathogenesis of cancer. Tumor suppressor genes, especially those involved in call cycle regulation, are inactivated frequently in a variety of cancers (Cunningham and Roussel 2001). Two closely linked tumor suppressor genes, p15ⁱⁿᵏ⁴ᵇ and p16ⁱⁿᵏ⁴ᵃ, are located at chromosome 9p21; they encode their respective cyclin-dependent kinase inhibitors (CDKI)- p15ⁱⁿᵏ⁴ᵇ and p16ⁱⁿᵏ⁴ᵃ.

Item ID: 22670
Item Type: Article (Refereed Research - C1)
ISSN: 1573-4927
Funders: University of Sistan and Baluchestan, Zahedan University of Medical Sciences
Date Deposited: 01 Aug 2012 10:08
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1112 Oncology and Carcinogenesis > 111203 Cancer Genetics @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1112 Oncology and Carcinogenesis > 111201 Cancer Cell Biology @ 25%
06 BIOLOGICAL SCIENCES > 0604 Genetics > 060408 Genomics @ 25%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920102 Cancer and Related Disorders @ 100%
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