Acetylated Sesterterpenes from the Great Barrier Reef sponge Luffariella variabilis

Ettinger-Epstein, Piers, Motti, Cherie A., de Nys, Rocky, Wright, Anthony D., Battershill, Christopher N., and Tapiolas, Dianne M. (2007) Acetylated Sesterterpenes from the Great Barrier Reef sponge Luffariella variabilis. Journal of Natural Products, 70 (4). pp. 648-651.

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View at Publisher Website: http://dx.doi.org/10.1021/np060240d
 
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Abstract

Chemical investigation of the sponge Luffariella Variabilis collected from the Palm Island group of the Great Barrier Reef, Australia, yielded three new acetylated compounds, 25-acetoxyluffariellin A (1), 25-acetoxyluffariellin B (2), and 25-acetoxyseco-manoalide (3). The structures of the new compounds were elucidated on the basis of interpretation of their spectroscopic data. The known metabolites manoalide (4), seco-manoalide (5), luffariellin A (8), and manoalide monoacetate (10) were also isolated. The new acetylated compounds (1-3) were labile in the sponge tissue when samples were allowed to thaw prior to extraction, but were stable once isolated. Sponge samples that were completely thawed contained only hydroxylated compounds (alcohols). This finding supported the deduction that the acetylated compounds are being enzymatically transformed and/or degraded.

Item ID: 2200
Item Type: Article (Research - C1)
ISSN: 1520-6025
Keywords: marine natural products; sponges; manoalides
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Date Deposited: 06 May 2009 04:00
FoR Codes: 03 CHEMICAL SCIENCES > 0304 Medicinal and Biomolecular Chemistry > 030499 Medicinal and Biomolecular Chemistry not elsewhere classified @ 100%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970103 Expanding Knowledge in the Chemical Sciences @ 100%
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