Use of olanzapine in the treatment of acute mania: comparison of monotherapy and combination therapy with sodium valproate

Bennett, Hannah (2012) Use of olanzapine in the treatment of acute mania: comparison of monotherapy and combination therapy with sodium valproate. Australian Medical Student Journal, 3 (1). pp. 61-63.

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Aim: The aim of this article is to review the literature and outline the evidence, if any, for the effectiveness of olanzapine as a monotherapy for acute mania in comparison with the effectiveness of its use as a combined therapy with sodium valproate.

Case study: GR, a 55 year old male with no previous psychiatric history was assessed by the Consultation and Liaison team and diagnosed with an acute manic episode. He was placed under an involuntary treatment order and was prescribed olanzapine 10mg once daily (OD). After failing to respond adequately to this treatment, sodium valproate 500mg twice daily (BD) was added to the regimen.

Methods: A literature search was conducted using Medline Ovid and NCBI Pubmed databases. The search terms mania AND olanzapine AND valproate; acute mania AND pharmacotherapy and olanzapine AND mania were used.

Results: Two studies were identified that addressed the efficacy and safety of olanzapine for the treatment of acute mania. Both studies confirmed the superior efficacy of olanzapine in the treatment of acute mania in comparison to placebo. There were no studies identified that directly addressed the question of whether use of combination therapy of olanzapine and sodium valproate was more efficacious than olanzapine monotherapy.

Conclusion: There is no evidence currently available to support the use of combination olanzapine/ sodium valproate as a more efficacious treatment than olanzapine alone.

Item ID: 21983
Item Type: Article (Case Study)
ISSN: 1837-1728
Date Deposited: 15 Jun 2012 01:46
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110319 Psychiatry (incl Psychotherapy) @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920111 Nervous System and Disorders @ 100%
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