Dissecting genetic mechanisms conferring susceptibility to autoimmune diseases

Silveira, Pablo A., Jordan, Margaret A., and Baxter, Alan G. (1999) Dissecting genetic mechanisms conferring susceptibility to autoimmune diseases. Current Allergy and Clinical Immunology, 12. pp. 10-16.

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[Extract] Autoimmunity is defined as a specific immune response directed against one or more self antigens that occurs as a result of the failure or breakdown in the mechanisms responsible for maintaining immunological tolerance. Although autoimmunity is not necessarily destructive, in a small proportion of individuals, it can lead to pathological tissue damage. Depending on the target tissue of the autoimmune attack, a variety of autoimmune diseases can ensue which differ greatly in their clinical presentation.

Item ID: 21886
Item Type: Article (Research - C1)
ISSN: 1609-3607
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Date Deposited: 07 Jun 2012 00:57
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110703 Autoimmunity @ 100%
SEO Codes: 92 HEALTH > 9299 Other Health > 929999 Health not elsewhere classified @ 100%
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