There is more than the amygdala: potential threat assessment in the cingulate cortex

Fiddick, Laurence (2011) There is more than the amygdala: potential threat assessment in the cingulate cortex. Neuroscience & Biobehavioral Reviews, 35 (4). pp. 1007-1018.

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Fear conditioning with its neurological basis in the amygdala and associated structures provides an important model of anxiety disorders. However, this review will argue for a distinction between fear-provoking immediate and anxiety-provoking potentialthreats, with the amygdala processing immediate threats and the cingulatecortex (and insular) processing potentialthreats. Four independent but related literatures are reviewed to bolster this argument: (1) rodent remote contextual fear conditioning, (2) symptom provocation in obsessive compulsive disorder (OCD), (3) fMRI investigations of risk assessment, and (4) behavioural and neurological studies of precautionary reasoning. These four literatures converge in suggesting that the cingulatecortex (and in more specific instances the insula) underlie potentialthreatassessment, providing support for a number of recent models posting the existence of a separate potentialthreat system that is dysfunctional in obsessive compulsive disorder (e.g., [Szechtman and Woody, 2004] and [Woody and Szechtman, 2011]).

Item ID: 21722
Item Type: Article (Research - C1)
ISSN: 1873-7528
Keywords: amygdala, anterior cingulate, anxiety, fear, insula, obsessive compulsive disorder, posterior cingulate, precautions, security motivation, threat
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Date Deposited: 21 May 2012 05:32
FoR Codes: 17 PSYCHOLOGY AND COGNITIVE SCIENCES > 1701 Psychology > 170101 Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology) @ 50%
17 PSYCHOLOGY AND COGNITIVE SCIENCES > 1702 Cognitive Science > 170205 Neurocognitive Patterns and Neural Networks @ 50%
SEO Codes: 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920410 Mental Health @ 50%
97 EXPANDING KNOWLEDGE > 970111 Expanding Knowledge in the Medical and Health Sciences @ 50%
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